KMID : 0811720130170060485
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Korean Journal of Physiology & Pharmacology 2013 Volume.17 No. 6 p.485 ~ p.492
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Effect of Neurosteroid Modulation on Global Ischaemia-Reperfusion-Induced Cerebral Injury in Mice
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Amarjot Kaur Grewal
Avtar Chand Rana Amteshwar Singh Jaggi Nirmal Singh
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Abstract
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The present study was designed to investigate the putative effect of neurosteroid modulation on global ischaemia-reperfusion-induced cerebral injury in mice. Bilateral carotid artery occlusion followed by reperfusion, produced a significant rise in cerebral infarct size along with impairment of grip strength and motor coordination in Swiss albino mice. Administration of carbamazepine (16 mg/kg, i.p.) before global cerebral ischaemia significantly attenuated cerebral infarct size and improved the motor performance. However, administration of indomethacin (100 mg/kg, i.p.) attenuated the neuroprotective effect of carbamazepine. Mexiletine (50 mg/kg, i.p.) did not produce significant neuro-protective effect. It may be concluded that the neuroprotective effect of carbamazepine may be due to increase in synthesis of neurosteroids perhaps by activating enzyme (3¥á HSD) as indomethacin attenuated the neuroprotective effect of carbamazepine. The sodium channel blocking effect of car-bamazepine may not be involved in neuroprotection as mexiletine, a sodium channel blocker, did not produce significant neuroprotective effect.
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KEYWORD
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Carbamazepine, Global-ischaemia-reperfusion injury, Indomethacin, Mexiletine, Neuro-steroids
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